Drug interactions
Posaconazole + Verapamil
Severity: Moderate
Posaconazole and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole can increase verapamil concentrations, causing hypotension, bradycardia or AV block. Verapamil may modestly raise posaconazole levels through P-glycoprotein inhibition.
What this interaction means in plain words
Posaconazole and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Posaconazole belongs to Anti Fungals; Verapamil belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by posaconazole reduces verapamil metabolism, and verapamil inhibits P-glycoprotein efflux of posaconazole.
What to do
Monitor heart rate, blood pressure and ECG, and reduce the verapamil dose if bradycardia or hypotension appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Posaconazole with Verapamil?
MediHelp rates the interaction as moderate. Posaconazole and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole can increase verapamil concentrations, causing hypotension, bradycardia or AV block. Verapamil may modestly raise posaconazole levels through P-glycoprotein inhibition.
How serious is the interaction between Posaconazole and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and reduce the verapamil dose if bradycardia or hypotension appears.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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