Drug interactions
Pramipexole + Prochlorperazine
Severity: Major
Pramipexole and Prochlorperazine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prochlorperazine blocks dopamine D2 receptors and opposes pramipexole, which can worsen parkinsonism and reduce the benefit of treatment. Prochlorperazine can also cause extrapyramidal effects itself.
What this interaction means in plain words
Pramipexole and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pramipexole belongs to Cardiovascular; Prochlorperazine belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between D2 receptor blockade and D2/D3 agonism.
What to do
Avoid prochlorperazine in patients taking dopamine agonists for Parkinson disease. Use ondansetron or domperidone where available for nausea.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Pramipexole
- Amisulpride + Pramipexole Contraindicated
- Chlorpromazine + Pramipexole Major
- Droperidol + Pramipexole Major
- Fluphenazine + Pramipexole Major
- Haloperidol + Pramipexole Major
- Iloperidone + Pramipexole Major
Frequently asked questions
Can I take Pramipexole with Prochlorperazine?
MediHelp rates the interaction as major. Pramipexole and Prochlorperazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Prochlorperazine blocks dopamine D2 receptors and opposes pramipexole, which can worsen parkinsonism and reduce the benefit of treatment. Prochlorperazine can also cause extrapyramidal effects itself.
How serious is the interaction between Pramipexole and Prochlorperazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prochlorperazine in patients taking dopamine agonists for Parkinson disease. Use ondansetron or domperidone where available for nausea.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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