Drug interactions
Pravastatin + Ranolazine
Severity: Minor
Pravastatin and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine may modestly raise pravastatin exposure by affecting hepatic uptake transport. This could increase the risk of statin-related muscle toxicity, although the effect is expected to be small.
What this interaction means in plain words
Pravastatin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Ranolazine belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of pravastatin by ranolazine.
What to do
No routine dose change is needed. Advise patients to report muscle pain or weakness and measure creatine kinase if symptoms appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Pravastatin
Frequently asked questions
Can I take Pravastatin with Ranolazine?
MediHelp rates the interaction as minor. Pravastatin and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine may modestly raise pravastatin exposure by affecting hepatic uptake transport. This could increase the risk of statin-related muscle toxicity, although the effect is expected to be small.
How serious is the interaction between Pravastatin and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Advise patients to report muscle pain or weakness and measure creatine kinase if symptoms appear.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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