Drug interactions
Pravastatin + Tenapanor
Severity: Minor
Pravastatin and Tenapanor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenapanor may reduce intestinal absorption of OATP2B1 substrates such as pravastatin, potentially lowering its lipid-lowering effect.
What this interaction means in plain words
Pravastatin and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Tenapanor belongs to Gastrointestinal Tract.
Why it happens
Tenapanor inhibits intestinal OATP2B1 uptake, reducing pravastatin absorption.
What to do
Monitor lipid levels and consider increasing the pravastatin dose if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Tenapanor
- Enalapril-hydrochlorothiazide + Tenapanor Moderate
- Enalapril + Tenapanor Moderate
- Rosuvastatin + Tenapanor Moderate
- Atorvastatin + Tenapanor Minor
- Bosentan + Tenapanor Minor
- Fexofenadine + Tenapanor Minor
Frequently asked questions
Can I take Pravastatin with Tenapanor?
MediHelp rates the interaction as minor. Pravastatin and Tenapanor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenapanor may reduce intestinal absorption of OATP2B1 substrates such as pravastatin, potentially lowering its lipid-lowering effect.
How serious is the interaction between Pravastatin and Tenapanor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor lipid levels and consider increasing the pravastatin dose if control worsens.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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