Drug interactions
Pravastatin + Vemurafenib
Severity: Minor
Pravastatin and Vemurafenib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib is a weak P-gp inhibitor and could modestly raise exposure to P-gp substrates such as pravastatin. The expected effect is small, and the clinical significance has not been well established.
What this interaction means in plain words
Pravastatin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pravastatin belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Vemurafenib inhibits P-glycoprotein efflux, which may modestly increase pravastatin absorption.
What to do
No dose adjustment is usually required. Advise patients to report muscle symptoms and check CK if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Vemurafenib
Frequently asked questions
Can I take Pravastatin with Vemurafenib?
MediHelp rates the interaction as minor. Pravastatin and Vemurafenib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Vemurafenib is a weak P-gp inhibitor and could modestly raise exposure to P-gp substrates such as pravastatin. The expected effect is small, and the clinical significance has not been well established.
How serious is the interaction between Pravastatin and Vemurafenib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required. Advise patients to report muscle symptoms and check CK if they occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporin, Gemfibrozil, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Pravastatin page.
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