Drug interactions
Prednisone + Tucatinib
Severity: Minor
Prednisone and Tucatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tucatinib inhibits P-gp and CYP3A4 weakly to moderately and could modestly increase prednisolone exposure. The clinical effect is expected to be small.
What this interaction means in plain words
Prednisone and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prednisone belongs to Endocrine; Tucatinib belongs to Oncology.
Why it happens
Tucatinib inhibits P-glycoprotein and CYP3A4, which may reduce prednisolone clearance.
What to do
No routine dose change is needed; monitor for corticosteroid adverse effects such as hyperglycemia and edema with prolonged therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Tucatinib
- Cisapride + Tucatinib Contraindicated
- Eletriptan + Tucatinib Contraindicated
- Ergotamine + Tucatinib Contraindicated
- Flibanserin + Tucatinib Contraindicated
- Ranolazine + Tucatinib Contraindicated
- Amobarbital + Tucatinib Major
Frequently asked questions
Can I take Prednisone with Tucatinib?
MediHelp rates the interaction as minor. Prednisone and Tucatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tucatinib inhibits P-gp and CYP3A4 weakly to moderately and could modestly increase prednisolone exposure. The clinical effect is expected to be small.
How serious is the interaction between Prednisone and Tucatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor for corticosteroid adverse effects such as hyperglycemia and edema with prolonged therapy.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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