Drug interactions
Pregabalin + Sirolimus
Severity: Moderate
Pregabalin and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pregabalin and sirolimus can each cause angioedema, so combining them may increase the risk of swelling involving the face, mouth and airway. Severe cases can compromise breathing.
What this interaction means in plain words
Pregabalin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pregabalin belongs to Central Nervous System; Sirolimus belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic risk of angioedema; no pharmacokinetic interaction is established.
What to do
Counsel the patient to report any facial, lip or throat swelling immediately and stop the drugs if it occurs. Monitor closely when starting the combination, especially in patients with prior angioedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Pregabalin with Sirolimus?
MediHelp rates the interaction as moderate. Pregabalin and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pregabalin and sirolimus can each cause angioedema, so combining them may increase the risk of swelling involving the face, mouth and airway. Severe cases can compromise breathing.
How serious is the interaction between Pregabalin and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient to report any facial, lip or throat swelling immediately and stop the drugs if it occurs. Monitor closely when starting the combination, especially in patients with prior angioedema.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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