Drug interactions
Pregabalin + Temazepam
Severity: Major
Pregabalin and Temazepam: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Temazepam is a benzodiazepine hypnotic, and pregabalin adds further CNS depression. The combination can increase sedation, falls, cognitive impairment and respiratory depression, particularly in older adults.
What this interaction means in plain words
Pregabalin and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pregabalin belongs to Central Nervous System; Temazepam belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS and respiratory depression via GABA-A potentiation and alpha-2-delta modulation.
What to do
Use the lowest effective doses and monitor for sedation and respiratory depression. Avoid or reduce doses in older patients and those with sleep apnea or lung disease.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Alzain 100 mg Capsules, Hard - SmPC sections 4.3/4.5 (class statement: central nervous system (CNS) depressant medicinal products; "there are reports of respiratory failure, coma and deaths in patients taking pregabalin and opioids and/or other central nervous system (CNS) depressant medicin") — electronic medicines compendium (UK SmPC)
Other interactions of Pregabalin
Other interactions of Temazepam
- Alprazolam + Temazepam Major
- Amobarbital + Temazepam Major
- Buprenorphine + Temazepam Major
- Butorphanol + Temazepam Major
- Carisoprodol + Temazepam Major
- Chloral hydrate + Temazepam Major
Frequently asked questions
Can I take Pregabalin with Temazepam?
MediHelp rates the interaction as major. Pregabalin and Temazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Temazepam is a benzodiazepine hypnotic, and pregabalin adds further CNS depression. The combination can increase sedation, falls, cognitive impairment and respiratory depression, particularly in older adults.
How serious is the interaction between Pregabalin and Temazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation and respiratory depression. Avoid or reduce doses in older patients and those with sleep apnea or lung disease.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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