Drug interactions
Pretomanid + Rosuvastatin
Severity: Moderate
Pretomanid and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits the transporters OATP1B3 and BCRP in vitro, and rosuvastatin is a substrate of both. Co-administration could raise rosuvastatin exposure and increase the likelihood of dose-related muscle toxicity.
What this interaction means in plain words
Pretomanid and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pretomanid belongs to Anti Bacterial; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of BCRP and OATP1B3 transporters reduces rosuvastatin efflux and hepatic uptake, raising systemic exposure.
What to do
Monitor for muscle pain, weakness and elevated creatine kinase during co-administration. Consider using the lowest effective rosuvastatin dose if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pretomanid and Rosuvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Rosuvastatin
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Rosuvastatin?
MediHelp rates the interaction as moderate. Pretomanid and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid inhibits the transporters OATP1B3 and BCRP in vitro, and rosuvastatin is a substrate of both. Co-administration could raise rosuvastatin exposure and increase the likelihood of dose-related muscle toxicity.
How serious is the interaction between Pretomanid and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and elevated creatine kinase during co-administration. Consider using the lowest effective rosuvastatin dose if symptoms appear.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
