Drug interactions
Pretomanid + Sofosbuvir-velpatasvir-voxilaprevir
Severity: Moderate
Pretomanid and Sofosbuvir-velpatasvir-voxilaprevir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid inhibits OATP1B3 in vitro, which may raise voxilaprevir exposure. The clinical effect is uncertain. Both drugs can affect the liver, which warrants attention.
What this interaction means in plain words
Pretomanid and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pretomanid belongs to Anti Bacterial; Sofosbuvir-velpatasvir-voxilaprevir belongs to Anti Virals.
Why it happens
Pretomanid inhibits OATP1B3-mediated hepatic uptake of voxilaprevir, increasing its plasma concentrations.
What to do
Monitor liver enzymes and adverse effects of both regimens during coadministration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sofosbuvir-velpatasvir-voxilaprevir
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenobarbital + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Phenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifampin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates the interaction as moderate. Pretomanid and Sofosbuvir-velpatasvir-voxilaprevir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid inhibits OATP1B3 in vitro, which may raise voxilaprevir exposure. The clinical effect is uncertain. Both drugs can affect the liver, which warrants attention.
How serious is the interaction between Pretomanid and Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and adverse effects of both regimens during coadministration.
What other medicines interact with Sofosbuvir-velpatasvir-voxilaprevir?
MediHelp also lists interactions of Sofosbuvir-velpatasvir-voxilaprevir with, for example, Fosphenytoin, Phenobarbital, Phenytoin. The full list is on the Sofosbuvir-velpatasvir-voxilaprevir page.
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