Drug interactions
Pretomanid + Testosterone
Severity: Moderate
Pretomanid and Testosterone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pretomanid-containing regimens are associated with liver injury, and androgens can occasionally add hepatic stress. The risk is mainly theoretical for standard testosterone preparations.
What this interaction means in plain words
Pretomanid and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pretomanid belongs to Anti Bacterial; Testosterone belongs to Endocrine.
Why it happens
Potential additive hepatotoxicity.
What to do
Check liver function at baseline and regularly during the pretomanid regimen. Interrupt treatment per tuberculosis guidance if significant liver injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Testosterone
- Testosterone + Warfarin Major
- Androstenedione + Testosterone Moderate
- Betamethasone + Testosterone Moderate
- Carbamazepine + Testosterone Moderate
- Corticotropin + Testosterone Moderate
- Cortisone + Testosterone Moderate
Other interactions of Pretomanid
Frequently asked questions
Can I take Pretomanid with Testosterone?
MediHelp rates the interaction as moderate. Pretomanid and Testosterone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pretomanid-containing regimens are associated with liver injury, and androgens can occasionally add hepatic stress. The risk is mainly theoretical for standard testosterone preparations.
How serious is the interaction between Pretomanid and Testosterone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check liver function at baseline and regularly during the pretomanid regimen. Interrupt treatment per tuberculosis guidance if significant liver injury develops.
What other medicines interact with Testosterone?
MediHelp also lists interactions of Testosterone with, for example, Warfarin, Androstenedione, Betamethasone. The full list is on the Testosterone page.
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