Drug interactions
Primaquine + Prochlorperazine
Severity: Moderate
Primaquine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so concurrent use may increase the risk of ventricular arrhythmias. The risk is higher with electrolyte disturbances or other QT-prolonging drugs.
What this interaction means in plain words
Primaquine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primaquine belongs to Anti Parasitic; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check potassium and magnesium and consider an ECG in patients with cardiac risk factors. Choose a non-QT-prolonging antiemetic if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Primaquine with Prochlorperazine?
MediHelp rates the interaction as moderate. Primaquine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT prolongation, so concurrent use may increase the risk of ventricular arrhythmias. The risk is higher with electrolyte disturbances or other QT-prolonging drugs.
How serious is the interaction between Primaquine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and consider an ECG in patients with cardiac risk factors. Choose a non-QT-prolonging antiemetic if possible.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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