Drug interactions
Procarbazine + Prochlorperazine
Severity: Moderate
Procarbazine and Prochlorperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has CNS depressant effects and weak monoamine oxidase inhibiting activity, so combining it with prochlorperazine can lead to excessive sedation. Hypotension and additive CNS effects may also occur.
What this interaction means in plain words
Procarbazine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Prochlorperazine belongs to Central Nervous System.
Why it happens
Additive central nervous system depression; procarbazine's weak MAO inhibition may contribute.
What to do
Monitor for oversedation and hypotension, and reduce the antiemetic dose if excessive drowsiness occurs. Advise avoiding alcohol and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Prochlorperazine?
MediHelp rates the interaction as moderate. Procarbazine and Prochlorperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has CNS depressant effects and weak monoamine oxidase inhibiting activity, so combining it with prochlorperazine can lead to excessive sedation. Hypotension and additive CNS effects may also occur.
How serious is the interaction between Procarbazine and Prochlorperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and hypotension, and reduce the antiemetic dose if excessive drowsiness occurs. Advise avoiding alcohol and driving.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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