Drug interactions
Procarbazine + Propofol
Severity: Moderate
Procarbazine and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak MAO-inhibiting activity and can cause CNS depression and orthostatic hypotension. Combined with propofol, it may deepen sedation and lower blood pressure more than expected.
What this interaction means in plain words
Procarbazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Procarbazine belongs to Oncology; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depressant and hypotensive effects; procarbazine also has weak MAO inhibition.
What to do
Reduce and slowly titrate propofol doses and monitor blood pressure and sedation depth closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Propofol?
MediHelp rates the interaction as moderate. Procarbazine and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has weak MAO-inhibiting activity and can cause CNS depression and orthostatic hypotension. Combined with propofol, it may deepen sedation and lower blood pressure more than expected.
How serious is the interaction between Procarbazine and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce and slowly titrate propofol doses and monitor blood pressure and sedation depth closely.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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