Drug interactions
Prochlorperazine + Quetiapine
Severity: Moderate
Prochlorperazine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two antipsychotics increases dopamine blockade, raising the risk of extrapyramidal symptoms and neuroleptic malignant syndrome, along with additive sedation. Both agents may also affect the QT interval and lower blood pressure.
What this interaction means in plain words
Prochlorperazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive D2 receptor antagonism with additive sedative, hypotensive and QT effects.
What to do
Avoid unnecessary duplication of antipsychotics and use the lowest prochlorperazine dose for the shortest time. Monitor for movement disorders, sedation, orthostasis and fever or rigidity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Prochlorperazine with Quetiapine?
MediHelp rates the interaction as moderate. Prochlorperazine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two antipsychotics increases dopamine blockade, raising the risk of extrapyramidal symptoms and neuroleptic malignant syndrome, along with additive sedation. Both agents may also affect the QT interval and lower blood pressure.
How serious is the interaction between Prochlorperazine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary duplication of antipsychotics and use the lowest prochlorperazine dose for the shortest time. Monitor for movement disorders, sedation, orthostasis and fever or rigidity.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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