Drug interactions
Prochlorperazine + Ritonavir
Severity: Moderate
Prochlorperazine and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir strongly inhibits CYP3A4 and also inhibits CYP2D6, and may raise prochlorperazine concentrations. Higher levels could increase sedation, extrapyramidal effects and QT prolongation, and ritonavir itself can prolong QT.
What this interaction means in plain words
Prochlorperazine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6 and CYP3A4 metabolism of prochlorperazine, with possible additive QT effects.
What to do
Use the lowest effective prochlorperazine dose and monitor for sedation, extrapyramidal symptoms and palpitations. Consider an ECG in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Ritonavir?
MediHelp rates the interaction as moderate. Prochlorperazine and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir strongly inhibits CYP3A4 and also inhibits CYP2D6, and may raise prochlorperazine concentrations. Higher levels could increase sedation, extrapyramidal effects and QT prolongation, and ritonavir itself can prolong QT.
How serious is the interaction between Prochlorperazine and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective prochlorperazine dose and monitor for sedation, extrapyramidal symptoms and palpitations. Consider an ECG in patients with other QT risk factors.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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