Drug interactions
Prochlorperazine + Saxagliptin-metformin
Severity: Moderate
Prochlorperazine and Saxagliptin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines such as prochlorperazine can raise blood glucose and impair glycemic control in patients taking antidiabetic drugs. Hypoglycemia may occur if the phenothiazine is later withdrawn.
What this interaction means in plain words
Prochlorperazine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Pharmacodynamic antagonism through reduced insulin secretion and peripheral insulin sensitivity caused by phenothiazine antipsychotic effects.
What to do
Monitor blood glucose regularly when prochlorperazine is used, especially with prolonged therapy. Adjust antidiabetic therapy if control worsens or after withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Saxagliptin-metformin
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Frequently asked questions
Can I take Prochlorperazine with Saxagliptin-metformin?
MediHelp rates the interaction as moderate. Prochlorperazine and Saxagliptin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines such as prochlorperazine can raise blood glucose and impair glycemic control in patients taking antidiabetic drugs. Hypoglycemia may occur if the phenothiazine is later withdrawn.
How serious is the interaction between Prochlorperazine and Saxagliptin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose regularly when prochlorperazine is used, especially with prolonged therapy. Adjust antidiabetic therapy if control worsens or after withdrawal.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
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