Drug interactions
Prochlorperazine + Sertraline
Severity: Moderate
Prochlorperazine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmias including torsades de pointes. Sertraline also inhibits CYP2D6 modestly, which may raise phenothiazine exposure and add to the risk of extrapyramidal effects and sedation.
What this interaction means in plain words
Prochlorperazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prochlorperazine belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation through cardiac potassium channel effects, with possible minor CYP2D6 inhibition by sertraline.
What to do
Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium before combining. Monitor for palpitations, syncope and movement disorders, and avoid adding further QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Prochlorperazine with Sertraline?
MediHelp rates the interaction as moderate. Prochlorperazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may add to the risk of ventricular arrhythmias including torsades de pointes. Sertraline also inhibits CYP2D6 modestly, which may raise phenothiazine exposure and add to the risk of extrapyramidal effects and sedation.
How serious is the interaction between Prochlorperazine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG in patients with cardiac risk factors and correct potassium and magnesium before combining. Monitor for palpitations, syncope and movement disorders, and avoid adding further QT-prolonging drugs.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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