Drug interactions
Prochlorperazine + Sufentanil
Severity: Major
Prochlorperazine and Sufentanil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a phenothiazine with an opioid increases sedation and can worsen respiratory depression and hypotension. The risk is greatest in opioid-naive, elderly or debilitated patients and after parenteral dosing.
What this interaction means in plain words
Prochlorperazine and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Prochlorperazine belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid receptor agonism and phenothiazine sedative and alpha-blocking effects.
What to do
Start with reduced doses of one or both drugs and monitor sedation, respiratory rate and blood pressure. Have resuscitation equipment and naloxone available when sufentanil is given parenterally.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Prochlorperazine with Sufentanil?
MediHelp rates the interaction as major. Prochlorperazine and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining a phenothiazine with an opioid increases sedation and can worsen respiratory depression and hypotension. The risk is greatest in opioid-naive, elderly or debilitated patients and after parenteral dosing.
How serious is the interaction between Prochlorperazine and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with reduced doses of one or both drugs and monitor sedation, respiratory rate and blood pressure. Have resuscitation equipment and naloxone available when sufentanil is given parenterally.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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