Drug interactions
Prochlorperazine + Vecuronium
Severity: Minor
Prochlorperazine and Vecuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines have weak neuromuscular effects and may modestly influence the depth or duration of neuromuscular blockade, while also contributing hypotension and sedation in the perioperative period. The clinical effect is generally small and manageable.
What this interaction means in plain words
Prochlorperazine and Vecuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prochlorperazine belongs to Central Nervous System; Vecuronium belongs to Musculoskeletal.
Why it happens
Possible weak additive neuromuscular blockade and membrane-stabilizing effects; the mechanism is not firmly established.
What to do
Monitor neuromuscular function with a nerve stimulator and titrate vecuronium to effect. Inform the anesthesia team of recent phenothiazine use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prochlorperazine
- Dronedarone + Prochlorperazine Contraindicated
- Ibutilide + Prochlorperazine Contraindicated
- Nilotinib + Prochlorperazine Contraindicated
- Pimozide + Prochlorperazine Contraindicated
- Prochlorperazine + Thioridazine Contraindicated
- Amiodarone + Prochlorperazine Major
Other interactions of Vecuronium
Frequently asked questions
Can I take Prochlorperazine with Vecuronium?
MediHelp rates the interaction as minor. Prochlorperazine and Vecuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines have weak neuromuscular effects and may modestly influence the depth or duration of neuromuscular blockade, while also contributing hypotension and sedation in the perioperative period. The clinical effect is generally small and manageable.
How serious is the interaction between Prochlorperazine and Vecuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular function with a nerve stimulator and titrate vecuronium to effect. Inform the anesthesia team of recent phenothiazine use.
What other medicines interact with Prochlorperazine?
MediHelp also lists interactions of Prochlorperazine with, for example, Dronedarone, Ibutilide, Nilotinib. The full list is on the Prochlorperazine page.
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