Drug interactions
Progesterone + Rifapentine
Severity: Major
Progesterone and Rifapentine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifapentine induces drug-metabolizing enzymes and can reduce progesterone concentrations. This may cause loss of progestogenic effect, including breakthrough bleeding, inadequate endometrial protection or contraceptive failure.
What this interaction means in plain words
Progesterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Progesterone belongs to Endocrine; Rifapentine belongs to Anti Bacterial.
Why it happens
Rifapentine induces CYP3A4, increasing the metabolism of progesterone.
What to do
Use a non-hormonal contraceptive method such as a copper IUD during and for a period after rifapentine therapy. Review progestogen dosing for endometrial protection and monitor for bleeding irregularities.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Progesterone
Other interactions of Rifapentine
- Ledipasvir-sofosbuvir + Rifapentine Contraindicated
- Lorlatinib + Rifapentine Contraindicated
- Lurasidone + Rifapentine Contraindicated
- Ranolazine + Rifapentine Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir Contraindicated
- Rifapentine + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Progesterone with Rifapentine?
MediHelp rates the interaction as major. Progesterone and Rifapentine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifapentine induces drug-metabolizing enzymes and can reduce progesterone concentrations. This may cause loss of progestogenic effect, including breakthrough bleeding, inadequate endometrial protection or contraceptive failure.
How serious is the interaction between Progesterone and Rifapentine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-hormonal contraceptive method such as a copper IUD during and for a period after rifapentine therapy. Review progestogen dosing for endometrial protection and monitor for bleeding irregularities.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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