Drug interactions
Progesterone + Ritonavir
Severity: Moderate
Progesterone and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a strong CYP3A4 inhibitor and may raise progesterone exposure. This may increase progestogenic adverse effects such as sedation, dizziness, mood change, fluid retention and bleeding irregularities.
What this interaction means in plain words
Progesterone and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Progesterone belongs to Endocrine; Ritonavir belongs to Anti Virals.
Why it happens
Ritonavir inhibits CYP3A4-mediated metabolism of progesterone.
What to do
Monitor for progestogenic adverse effects such as sedation and dizziness and reduce the progesterone dose if they occur. Be aware that prolonged exposure may also alter bleeding patterns.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Progesterone with Ritonavir?
MediHelp rates the interaction as moderate. Progesterone and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is a strong CYP3A4 inhibitor and may raise progesterone exposure. This may increase progestogenic adverse effects such as sedation, dizziness, mood change, fluid retention and bleeding irregularities.
How serious is the interaction between Progesterone and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for progestogenic adverse effects such as sedation and dizziness and reduce the progesterone dose if they occur. Be aware that prolonged exposure may also alter bleeding patterns.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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