Drug interactions
Progesterone + Sparsentan
Severity: Moderate
Progesterone and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP3A4 and may lower progesterone levels. Hormonal contraception is also unreliable with endothelin receptor antagonists, and sparsentan carries embryo-fetal toxicity risk.
What this interaction means in plain words
Progesterone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Progesterone belongs to Endocrine; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP enzymes, mainly CYP3A4, increasing progesterone clearance.
What to do
Monitor for reduced progestogen effect. In people who can become pregnant, follow the sparsentan contraception requirements and consider non-hormonal or combined methods.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Progesterone
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Progesterone with Sparsentan?
MediHelp rates the interaction as moderate. Progesterone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan induces CYP3A4 and may lower progesterone levels. Hormonal contraception is also unreliable with endothelin receptor antagonists, and sparsentan carries embryo-fetal toxicity risk.
How serious is the interaction between Progesterone and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced progestogen effect. In people who can become pregnant, follow the sparsentan contraception requirements and consider non-hormonal or combined methods.
What other medicines interact with Progesterone?
MediHelp also lists interactions of Progesterone with, for example, Apalutamide, Carbamazepine, Enzalutamide. The full list is on the Progesterone page.
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