Drug interactions
Propafenone + Talazoparib
Severity: Moderate
Propafenone and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propafenone inhibits P-gp and may increase talazoparib exposure, raising the risk of hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Propafenone and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propafenone belongs to Cardiovascular; Talazoparib belongs to Oncology.
Why it happens
P-gp inhibition by propafenone reduces talazoparib efflux and increases its exposure.
What to do
Monitor blood counts regularly, and consider reducing the talazoparib dose per labeling if P-gp inhibitors are needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Propafenone with Talazoparib?
MediHelp rates the interaction as moderate. Propafenone and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Propafenone inhibits P-gp and may increase talazoparib exposure, raising the risk of hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Propafenone and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly, and consider reducing the talazoparib dose per labeling if P-gp inhibitors are needed.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
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