Drug interactions
Propofol + Quetiapine
Severity: Moderate
Propofol and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine and propofol both depress the CNS, so sedation and hypotension may be greater than expected. Lower propofol doses may be needed for anesthesia or procedural sedation.
What this interaction means in plain words
Propofol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects.
What to do
Titrate propofol cautiously and monitor blood pressure, airway and respiratory status. Inform the anesthesia team of quetiapine use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Quetiapine?
MediHelp rates the interaction as moderate. Propofol and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine and propofol both depress the CNS, so sedation and hypotension may be greater than expected. Lower propofol doses may be needed for anesthesia or procedural sedation.
How serious is the interaction between Propofol and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol cautiously and monitor blood pressure, airway and respiratory status. Inform the anesthesia team of quetiapine use.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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