Drug interactions
Propofol + Ramelteon
Severity: Minor
Propofol and Ramelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a potent sedative-hypnotic, and ramelteon has hypnotic effects of its own. Taken together they may deepen sedation, though ramelteon has little respiratory depressant activity. The relevance is greatest in procedural or ICU sedation.
What this interaction means in plain words
Propofol and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propofol belongs to Central Nervous System; Ramelteon belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABAergic sedation (propofol) and melatonin receptor agonism (ramelteon).
What to do
Titrate propofol to clinical effect and monitor sedation depth in patients who took ramelteon. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Ramelteon?
MediHelp rates the interaction as minor. Propofol and Ramelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propofol is a potent sedative-hypnotic, and ramelteon has hypnotic effects of its own. Taken together they may deepen sedation, though ramelteon has little respiratory depressant activity. The relevance is greatest in procedural or ICU sedation.
How serious is the interaction between Propofol and Ramelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to clinical effect and monitor sedation depth in patients who took ramelteon. No routine dose change is required.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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