Drug interactions
Propofol + Thioridazine
Severity: Moderate
Propofol and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines add to the sedative and hypotensive effects of propofol. Propofol requirements may be lower, and thioridazine's QT effect adds concern during anesthesia.
What this interaction means in plain words
Propofol and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Thioridazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and vasodilatory hypotension; thioridazine also prolongs QT.
What to do
Titrate propofol to effect with reduced doses and monitor blood pressure, respiration and ECG.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Thioridazine?
MediHelp rates the interaction as moderate. Propofol and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phenothiazines add to the sedative and hypotensive effects of propofol. Propofol requirements may be lower, and thioridazine's QT effect adds concern during anesthesia.
How serious is the interaction between Propofol and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with reduced doses and monitor blood pressure, respiration and ECG.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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