Drug interactions
Propofol + Tranylcypromine
Severity: Moderate
Propofol and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients on MAO inhibitors can show exaggerated blood pressure swings under general anesthesia, and propofol adds to hypotension. The interaction is mainly hemodynamic and is manageable with monitoring.
What this interaction means in plain words
Propofol and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Tranylcypromine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic cardiovascular and CNS depressant effects; the mechanism is not fully defined.
What to do
Tell the anesthesia team about MAOI use, titrate propofol carefully and monitor blood pressure continuously. Use direct-acting vasopressors if needed and avoid meperidine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Tranylcypromine?
MediHelp rates the interaction as moderate. Propofol and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients on MAO inhibitors can show exaggerated blood pressure swings under general anesthesia, and propofol adds to hypotension. The interaction is mainly hemodynamic and is manageable with monitoring.
How serious is the interaction between Propofol and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about MAOI use, titrate propofol carefully and monitor blood pressure continuously. Use direct-acting vasopressors if needed and avoid meperidine.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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