Drug interactions
Propofol + Valproic acid
Severity: Moderate
Propofol and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valproate may reduce the propofol dose needed for anesthesia, and combined use can deepen sedation and hypotension. Valproate may also displace or alter drug handling, and reduced requirements have been reported.
What this interaction means in plain words
Propofol and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Propofol belongs to Central Nervous System; Valproic acid belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible reduction in propofol requirements.
What to do
Titrate propofol to effect with careful hemodynamic and depth-of-anesthesia monitoring and expect lower doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propofol and Valproic acid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Valproic acid?
MediHelp rates the interaction as moderate. Propofol and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valproate may reduce the propofol dose needed for anesthesia, and combined use can deepen sedation and hypotension. Valproate may also displace or alter drug handling, and reduced requirements have been reported.
How serious is the interaction between Propofol and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect with careful hemodynamic and depth-of-anesthesia monitoring and expect lower doses.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
