Drug interactions
Propofol + Warfarin
Severity: Minor
Propofol and Warfarin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propofol is a short-acting anesthetic with no well-documented effect on warfarin response. Any CYP inhibition is brief and not clinically established.
What this interaction means in plain words
Propofol and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propofol belongs to Central Nervous System; Warfarin belongs to Cardiovascular.
Why it happens
Theoretical weak CYP inhibition; no established mechanism.
What to do
No routine action is needed; check INR as perioperatively indicated.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Propofol and Warfarin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Propofol
Frequently asked questions
Can I take Propofol with Warfarin?
MediHelp rates the interaction as minor. Propofol and Warfarin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propofol is a short-acting anesthetic with no well-documented effect on warfarin response. Any CYP inhibition is brief and not clinically established.
How serious is the interaction between Propofol and Warfarin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; check INR as perioperatively indicated.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
