Drug interactions
Propranolol + Rolapitant
Severity: Minor
Propranolol and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Propranolol is partly metabolized by CYP2D6 (alongside CYP1A2), so rolapitant may raise its concentrations to a modest degree. This may produce bradycardia, hypotension or fatigue.
What this interaction means in plain words
Propranolol and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Propranolol belongs to Cardiovascular; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Rolapitant inhibits CYP2D6, partially reducing propranolol metabolism.
What to do
Monitor heart rate and blood pressure. Reduce the propranolol dose if excessive beta-blockade occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Propranolol
- Propranolol + Thioridazine Contraindicated
- Acebutolol + Propranolol Major
- Adrenaline-articaine + Propranolol Major
- Amifostine + Propranolol Major
- Amiodarone + Propranolol Major
- Arformoterol + Propranolol Major
Frequently asked questions
Can I take Propranolol with Rolapitant?
MediHelp rates the interaction as minor. Propranolol and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Propranolol is partly metabolized by CYP2D6 (alongside CYP1A2), so rolapitant may raise its concentrations to a modest degree. This may produce bradycardia, hypotension or fatigue.
How serious is the interaction between Propranolol and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure. Reduce the propranolol dose if excessive beta-blockade occurs.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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