Drug interactions
Pseudoephedrine + Silodosin
Severity: Moderate
Pseudoephedrine and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pseudoephedrine's alpha-adrenergic and pressor effects oppose the alpha-1A blockade of silodosin, and may reduce its benefit on urinary symptoms. Pseudoephedrine can also worsen urinary retention in men with benign prostatic hyperplasia.
What this interaction means in plain words
Pseudoephedrine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pseudoephedrine belongs to Respiratory; Silodosin belongs to Genitourinary.
Why it happens
Pharmacodynamic antagonism between sympathomimetic alpha-agonism and alpha-1 receptor blockade.
What to do
Avoid oral decongestants in men with BPH where possible; monitor urinary symptoms and blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Frequently asked questions
Can I take Pseudoephedrine with Silodosin?
MediHelp rates the interaction as moderate. Pseudoephedrine and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pseudoephedrine's alpha-adrenergic and pressor effects oppose the alpha-1A blockade of silodosin, and may reduce its benefit on urinary symptoms. Pseudoephedrine can also worsen urinary retention in men with benign prostatic hyperplasia.
How serious is the interaction between Pseudoephedrine and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid oral decongestants in men with BPH where possible; monitor urinary symptoms and blood pressure if used.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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