Drug interactions
Pseudoephedrine + Solriamfetol
Severity: Moderate
Pseudoephedrine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol raises blood pressure and heart rate, and pseudoephedrine has similar sympathomimetic effects. Taking them together may produce additive hypertension and tachycardia.
What this interaction means in plain words
Pseudoephedrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pseudoephedrine belongs to Respiratory; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects: solriamfetol inhibits dopamine and norepinephrine reuptake while pseudoephedrine releases norepinephrine.
What to do
Monitor blood pressure and heart rate and avoid pseudoephedrine in patients with uncontrolled hypertension. Prefer a non-sympathomimetic decongestant if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Pseudoephedrine with Solriamfetol?
MediHelp rates the interaction as moderate. Pseudoephedrine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol raises blood pressure and heart rate, and pseudoephedrine has similar sympathomimetic effects. Taking them together may produce additive hypertension and tachycardia.
How serious is the interaction between Pseudoephedrine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and avoid pseudoephedrine in patients with uncontrolled hypertension. Prefer a non-sympathomimetic decongestant if possible.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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