Drug interactions
Quetiapine + Vilazodone
Severity: Moderate
Quetiapine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quetiapine blocks dopamine and serotonin receptors, and with vilazodone it may rarely cause serotonin syndrome or neuroleptic malignant syndrome. The combination is used clinically, but the reactions can be serious.
What this interaction means in plain words
Quetiapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quetiapine belongs to Central Nervous System; Vilazodone belongs to Central Nervous System.
Why it happens
Additive serotonergic activity with dopamine and serotonin receptor antagonism, a pharmacodynamic interaction.
What to do
Monitor for mental status change, neuromuscular hyperactivity, hyperthermia and rigidity, especially at initiation and dose increases. Discontinue the drugs and provide supportive care if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Quetiapine with Vilazodone?
MediHelp rates the interaction as moderate. Quetiapine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quetiapine blocks dopamine and serotonin receptors, and with vilazodone it may rarely cause serotonin syndrome or neuroleptic malignant syndrome. The combination is used clinically, but the reactions can be serious.
How serious is the interaction between Quetiapine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, neuromuscular hyperactivity, hyperthermia and rigidity, especially at initiation and dose increases. Discontinue the drugs and provide supportive care if toxicity is suspected.
What other medicines interact with Vilazodone?
MediHelp also lists interactions of Vilazodone with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Vilazodone page.
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