Drug interactions
Quinidine + Talazoparib
Severity: Moderate
Quinidine and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Talazoparib is a P-glycoprotein substrate, and quinidine is a potent P-gp inhibitor. Co-use may raise talazoparib exposure and increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Quinidine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Talazoparib belongs to Oncology.
Why it happens
Quinidine inhibits P-glycoprotein efflux of talazoparib, increasing its systemic exposure.
What to do
Avoid combined use where possible. If it cannot be avoided, reduce the talazoparib dose as advised in its labeling and monitor blood counts closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Quinidine with Talazoparib?
MediHelp rates the interaction as moderate. Quinidine and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Talazoparib is a P-glycoprotein substrate, and quinidine is a potent P-gp inhibitor. Co-use may raise talazoparib exposure and increase hematologic toxicity such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Quinidine and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible. If it cannot be avoided, reduce the talazoparib dose as advised in its labeling and monitor blood counts closely.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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