Drug interactions
Quinidine + Tasimelteon
Severity: Minor
Quinidine and Tasimelteon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tasimelteon is metabolized by CYP1A2 and CYP3A4. Quinidine is a weak CYP3A4 inhibitor, so tasimelteon levels may rise modestly, with little expected clinical consequence.
What this interaction means in plain words
Quinidine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Quinidine belongs to Anti Parasitic; Tasimelteon belongs to Central Nervous System.
Why it happens
Quinidine may weakly inhibit CYP3A4-mediated metabolism of tasimelteon.
What to do
No dose change is usually needed. Watch for increased somnolence or dizziness when the two are combined.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Tasimelteon
Frequently asked questions
Can I take Quinidine with Tasimelteon?
MediHelp rates the interaction as minor. Quinidine and Tasimelteon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tasimelteon is metabolized by CYP1A2 and CYP3A4. Quinidine is a weak CYP3A4 inhibitor, so tasimelteon levels may rise modestly, with little expected clinical consequence.
How serious is the interaction between Quinidine and Tasimelteon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Watch for increased somnolence or dizziness when the two are combined.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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