Drug interactions
Quinidine + Teclistamab
Severity: Moderate
Quinidine and Teclistamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teclistamab causes cytokine release that can transiently suppress CYP450 enzymes and raise exposure to substrates such as quinidine. This could cause quinidine toxicity, including QT prolongation, particularly after the first doses.
What this interaction means in plain words
Quinidine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Teclistamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces quinidine metabolism.
What to do
Monitor ECG and quinidine levels during teclistamab step-up dosing and any cytokine release syndrome. Reduce the quinidine dose if concentrations or QTc rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Teclistamab
- Pimozide + Teclistamab Major
- Carbamazepine + Teclistamab Moderate
- Colchicine + Teclistamab Moderate
- Cyclosporin + Teclistamab Moderate
- Divalproex + Teclistamab Moderate
- Ergotamine + Teclistamab Moderate
Frequently asked questions
Can I take Quinidine with Teclistamab?
MediHelp rates the interaction as moderate. Quinidine and Teclistamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teclistamab causes cytokine release that can transiently suppress CYP450 enzymes and raise exposure to substrates such as quinidine. This could cause quinidine toxicity, including QT prolongation, particularly after the first doses.
How serious is the interaction between Quinidine and Teclistamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and quinidine levels during teclistamab step-up dosing and any cytokine release syndrome. Reduce the quinidine dose if concentrations or QTc rise.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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