Drug interactions
Quinidine + Vilazodone
Severity: Moderate
Quinidine and Vilazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine may modestly raise vilazodone levels via CYP3A4 inhibition, which could increase serotonergic adverse effects such as nausea, diarrhea and, rarely, serotonin syndrome. Quinidine is a weaker CYP3A4 inhibitor than agents like ketoconazole, so the effect is likely small.
What this interaction means in plain words
Quinidine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Quinidine belongs to Anti Parasitic; Vilazodone belongs to Central Nervous System.
Why it happens
Quinidine inhibits CYP3A4 metabolism of vilazodone, increasing exposure.
What to do
Monitor for serotonergic and gastrointestinal adverse effects. Reduce the vilazodone dose if intolerance appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Vilazodone
- Isocarboxazid + Vilazodone Contraindicated
- Methylene blue + Vilazodone Contraindicated
- Phenelzine + Vilazodone Contraindicated
- Rasagiline + Vilazodone Contraindicated
- Selegiline transdermal + Vilazodone Contraindicated
- Selegiline + Vilazodone Contraindicated
Frequently asked questions
Can I take Quinidine with Vilazodone?
MediHelp rates the interaction as moderate. Quinidine and Vilazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine may modestly raise vilazodone levels via CYP3A4 inhibition, which could increase serotonergic adverse effects such as nausea, diarrhea and, rarely, serotonin syndrome. Quinidine is a weaker CYP3A4 inhibitor than agents like ketoconazole, so the effect is likely small.
How serious is the interaction between Quinidine and Vilazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonergic and gastrointestinal adverse effects. Reduce the vilazodone dose if intolerance appears.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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