Drug interactions
Ramelteon + Teriflunomide
Severity: Minor
Ramelteon and Teriflunomide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide is a weak CYP1A2 inducer, and ramelteon is mainly cleared by CYP1A2. Ramelteon exposure may fall slightly, which could reduce its effect on sleep onset.
What this interaction means in plain words
Ramelteon and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ramelteon belongs to Central Nervous System; Teriflunomide belongs to Central Nervous System.
Why it happens
Weak induction of CYP1A2 by teriflunomide, increasing ramelteon metabolism.
What to do
No preemptive dose change. Monitor for reduced efficacy of ramelteon and consider alternatives if the response is poor.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramelteon
- Calcium / magnesium / potassium / sodium oxybates + Ramelteon Contraindicated
- Fluvoxamine + Ramelteon Contraindicated
- Ramelteon + Sodium oxybate Contraindicated
- Alfentanil + Ramelteon Moderate
- Amitriptyline + Ramelteon Moderate
- Amobarbital + Ramelteon Moderate
Other interactions of Teriflunomide
Frequently asked questions
Can I take Ramelteon with Teriflunomide?
MediHelp rates the interaction as minor. Ramelteon and Teriflunomide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Teriflunomide is a weak CYP1A2 inducer, and ramelteon is mainly cleared by CYP1A2. Ramelteon exposure may fall slightly, which could reduce its effect on sleep onset.
How serious is the interaction between Ramelteon and Teriflunomide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No preemptive dose change. Monitor for reduced efficacy of ramelteon and consider alternatives if the response is poor.
What other medicines interact with Ramelteon?
MediHelp also lists interactions of Ramelteon with, for example, Calcium / magnesium / potassium / sodium oxybates, Fluvoxamine, Sodium oxybate. The full list is on the Ramelteon page.
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