Drug interactions
Ramipril + Silodosin
Severity: Moderate
Ramipril and Silodosin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Silodosin and the ACE inhibitor ramipril both lower blood pressure by different mechanisms. Together they may produce additive hypotension, with dizziness or syncope most likely at initiation or after dose changes.
What this interaction means in plain words
Ramipril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ramipril belongs to Cardiovascular; Silodosin belongs to Genitourinary.
Why it happens
Additive pharmacodynamic hypotensive effects from alpha-1 adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Lower the dose of one agent if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Silodosin
- Atazanavir + Silodosin Contraindicated
- Conivaptan + Silodosin Contraindicated
- Darunavir + Silodosin Contraindicated
- Fosamprenavir + Silodosin Contraindicated
- Indinavir + Silodosin Contraindicated
- Itraconazole + Silodosin Contraindicated
Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Frequently asked questions
Can I take Ramipril with Silodosin?
MediHelp rates the interaction as moderate. Ramipril and Silodosin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Silodosin and the ACE inhibitor ramipril both lower blood pressure by different mechanisms. Together they may produce additive hypotension, with dizziness or syncope most likely at initiation or after dose changes.
How serious is the interaction between Ramipril and Silodosin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug. Lower the dose of one agent if symptomatic hypotension occurs.
What other medicines interact with Silodosin?
MediHelp also lists interactions of Silodosin with, for example, Atazanavir, Conivaptan, Darunavir. The full list is on the Silodosin page.
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