Drug interactions
Ranolazine + Rilpivirine
Severity: Moderate
Ranolazine and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine at supratherapeutic doses prolongs the QT interval, and ranolazine also prolongs QT in a dose-related manner. Combined use may increase the risk of torsades de pointes, particularly in patients with other risk factors.
What this interaction means in plain words
Ranolazine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT interval prolongation through effects on cardiac repolarization.
What to do
Check a baseline ECG and monitor periodically, especially with other QT-prolonging drugs or electrolyte disturbances. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Ranolazine with Rilpivirine?
MediHelp rates the interaction as moderate. Ranolazine and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine at supratherapeutic doses prolongs the QT interval, and ranolazine also prolongs QT in a dose-related manner. Combined use may increase the risk of torsades de pointes, particularly in patients with other risk factors.
How serious is the interaction between Ranolazine and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check a baseline ECG and monitor periodically, especially with other QT-prolonging drugs or electrolyte disturbances. Correct potassium and magnesium abnormalities.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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