Drug interactions
Ranolazine + Rimegepant
Severity: Moderate
Ranolazine and Rimegepant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine inhibits P-glycoprotein and may raise rimegepant exposure. The clinical consequence is likely modest, mainly more CGRP antagonist adverse effects such as nausea.
What this interaction means in plain words
Ranolazine and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Rimegepant belongs to Central Nervous System.
Why it happens
Ranolazine inhibits P-gp efflux, increasing rimegepant absorption and reducing its clearance.
What to do
Avoid a second rimegepant dose within 48 hours when taken with a P-gp inhibitor, per labeling. Monitor for tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Rimegepant
Frequently asked questions
Can I take Ranolazine with Rimegepant?
MediHelp rates the interaction as moderate. Ranolazine and Rimegepant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine inhibits P-glycoprotein and may raise rimegepant exposure. The clinical consequence is likely modest, mainly more CGRP antagonist adverse effects such as nausea.
How serious is the interaction between Ranolazine and Rimegepant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid a second rimegepant dose within 48 hours when taken with a P-gp inhibitor, per labeling. Monitor for tolerability.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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