Drug interactions
Ranolazine + Rosuvastatin
Severity: Minor
Ranolazine and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine may modestly increase rosuvastatin exposure through transporter inhibition. This could raise the risk of statin-related muscle toxicity, although the effect is generally small.
What this interaction means in plain words
Ranolazine and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Rosuvastatin belongs to Cardiovascular.
Why it happens
Ranolazine may inhibit OATP1B1 or other transporters involved in rosuvastatin hepatic uptake, raising systemic levels.
What to do
No routine dose change is needed. Counsel the patient to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Rosuvastatin
Frequently asked questions
Can I take Ranolazine with Rosuvastatin?
MediHelp rates the interaction as minor. Ranolazine and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine may modestly increase rosuvastatin exposure through transporter inhibition. This could raise the risk of statin-related muscle toxicity, although the effect is generally small.
How serious is the interaction between Ranolazine and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Counsel the patient to report unexplained muscle pain or weakness and check creatine kinase if symptoms occur.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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