Drug interactions
Ranolazine + Solifenacin
Severity: Moderate
Ranolazine and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine prolongs the QT interval in a dose-related way, and solifenacin may add to the effect. Ranolazine is also a weak CYP3A4 inhibitor and could modestly increase solifenacin exposure.
What this interaction means in plain words
Ranolazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, with weak CYP3A4 inhibition by ranolazine.
What to do
Monitor the ECG, especially after dose increases of either drug, and correct electrolyte abnormalities. Use the lowest effective dose of each drug in patients with a long QTc.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Solifenacin?
MediHelp rates the interaction as moderate. Ranolazine and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ranolazine prolongs the QT interval in a dose-related way, and solifenacin may add to the effect. Ranolazine is also a weak CYP3A4 inhibitor and could modestly increase solifenacin exposure.
How serious is the interaction between Ranolazine and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the ECG, especially after dose increases of either drug, and correct electrolyte abnormalities. Use the lowest effective dose of each drug in patients with a long QTc.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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