Drug interactions
Ranolazine + Tazemetostat
Severity: Moderate
Ranolazine and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A inducer and a CYP3A substrate, while ranolazine is a weak CYP3A inhibitor and is cleared mainly by CYP3A. Tazemetostat may reduce ranolazine efficacy, while ranolazine is unlikely to meaningfully raise tazemetostat levels.
What this interaction means in plain words
Ranolazine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ranolazine belongs to Cardiovascular; Tazemetostat belongs to Miscellaneous.
Why it happens
CYP3A4 induction by tazemetostat lowering ranolazine levels, with weak CYP3A4 inhibition by ranolazine.
What to do
Monitor for reduced antianginal response to ranolazine and adjust therapy if angina worsens. Avoid combining with strong CYP3A inhibitors in addition.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Ranolazine with Tazemetostat?
MediHelp rates the interaction as moderate. Ranolazine and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A inducer and a CYP3A substrate, while ranolazine is a weak CYP3A inhibitor and is cleared mainly by CYP3A. Tazemetostat may reduce ranolazine efficacy, while ranolazine is unlikely to meaningfully raise tazemetostat levels.
How serious is the interaction between Ranolazine and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antianginal response to ranolazine and adjust therapy if angina worsens. Avoid combining with strong CYP3A inhibitors in addition.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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