Drug interactions
Ranolazine + Tipranavir
Severity: Contraindicated
Ranolazine and Tipranavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, is a strong CYP3A4 and P-gp inhibitor and markedly increases ranolazine exposure. This raises the risk of QT prolongation and dose-related adverse effects.
What this interaction means in plain words
Ranolazine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ranolazine belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Potent inhibition of CYP3A4 and P-glycoprotein by ritonavir-boosted tipranavir reduces ranolazine clearance.
What to do
Do not combine; ranolazine labeling contraindicates strong CYP3A4 inhibitors. Use an alternative antianginal such as a beta-blocker or calcium channel blocker.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Ranolazine with Tipranavir?
MediHelp rates the interaction as contraindicated. Ranolazine and Tipranavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Tipranavir, given with ritonavir, is a strong CYP3A4 and P-gp inhibitor and markedly increases ranolazine exposure. This raises the risk of QT prolongation and dose-related adverse effects.
How serious is the interaction between Ranolazine and Tipranavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; ranolazine labeling contraindicates strong CYP3A4 inhibitors. Use an alternative antianginal such as a beta-blocker or calcium channel blocker.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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