Drug interactions
Ranolazine + Trimethoprim
Severity: Minor
Ranolazine and Trimethoprim: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim has been linked to rare QT prolongation, and ranolazine can also prolong the QT interval. The combined effect is likely small in most patients but may matter with additional risk factors.
What this interaction means in plain words
Ranolazine and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ranolazine belongs to Cardiovascular; Trimethoprim belongs to Anti Bacterial.
Why it happens
Possible additive effect on cardiac repolarization.
What to do
No routine change is needed. Check ECG and electrolytes if the patient has renal impairment, hyperkalemia, or other QT-prolonging drugs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Trimethoprim
Frequently asked questions
Can I take Ranolazine with Trimethoprim?
MediHelp rates the interaction as minor. Ranolazine and Trimethoprim have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Trimethoprim has been linked to rare QT prolongation, and ranolazine can also prolong the QT interval. The combined effect is likely small in most patients but may matter with additional risk factors.
How serious is the interaction between Ranolazine and Trimethoprim?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Check ECG and electrolytes if the patient has renal impairment, hyperkalemia, or other QT-prolonging drugs.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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