Drug interactions
Ranolazine + Vemurafenib
Severity: Major
Ranolazine and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so use together raises torsades risk. Vemurafenib also induces and inhibits CYP3A4 to some extent, which can alter ranolazine exposure unpredictably.
What this interaction means in plain words
Ranolazine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ranolazine belongs to Cardiovascular; Vemurafenib belongs to Oncology.
Why it happens
Additive QTc prolongation, plus variable CYP3A4 and P-gp effects of vemurafenib.
What to do
Avoid if possible. If used together, monitor ECG and electrolytes at baseline and periodically, and stop or reduce therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Ranolazine with Vemurafenib?
MediHelp rates the interaction as major. Ranolazine and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so use together raises torsades risk. Vemurafenib also induces and inhibits CYP3A4 to some extent, which can alter ranolazine exposure unpredictably.
How serious is the interaction between Ranolazine and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used together, monitor ECG and electrolytes at baseline and periodically, and stop or reduce therapy if QTc becomes markedly prolonged.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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