Drug interactions
Ranolazine + Voriconazole
Severity: Contraindicated
Ranolazine and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole, a strong CYP3A4 inhibitor, can substantially raise ranolazine concentrations, increasing dose-related QT prolongation and other adverse effects. Ranolazine labeling contraindicates strong CYP3A4 inhibitors.
What this interaction means in plain words
Ranolazine and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Ranolazine belongs to Cardiovascular; Voriconazole belongs to Anti Fungals.
Why it happens
Inhibition of CYP3A4-mediated ranolazine metabolism.
What to do
Avoid concurrent use; hold ranolazine during voriconazole therapy or use an alternative antifungal.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Ranolazine with Voriconazole?
MediHelp rates the interaction as contraindicated. Ranolazine and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole, a strong CYP3A4 inhibitor, can substantially raise ranolazine concentrations, increasing dose-related QT prolongation and other adverse effects. Ranolazine labeling contraindicates strong CYP3A4 inhibitors.
How serious is the interaction between Ranolazine and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; hold ranolazine during voriconazole therapy or use an alternative antifungal.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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