Drug interactions
Regorafenib + Talazoparib
Severity: Moderate
Regorafenib and Talazoparib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regorafenib inhibits BCRP in vitro and may increase talazoparib exposure, as talazoparib is a BCRP substrate. This may increase myelosuppression such as anemia, neutropenia and thrombocytopenia.
What this interaction means in plain words
Regorafenib and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Regorafenib belongs to Oncology; Talazoparib belongs to Oncology.
Why it happens
BCRP inhibition by regorafenib reduces efflux and clearance of talazoparib.
What to do
Monitor blood counts regularly. Reduce the talazoparib dose per labeling if significant hematologic toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Other interactions of Talazoparib
- Carvedilol + Talazoparib Major
- Itraconazole + Talazoparib Major
- Amiodarone + Talazoparib Moderate
- Azithromycin + Talazoparib Moderate
- Clarithromycin + Talazoparib Moderate
- Cyclosporin + Talazoparib Moderate
Frequently asked questions
Can I take Regorafenib with Talazoparib?
MediHelp rates the interaction as moderate. Regorafenib and Talazoparib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regorafenib inhibits BCRP in vitro and may increase talazoparib exposure, as talazoparib is a BCRP substrate. This may increase myelosuppression such as anemia, neutropenia and thrombocytopenia.
How serious is the interaction between Regorafenib and Talazoparib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts regularly. Reduce the talazoparib dose per labeling if significant hematologic toxicity occurs.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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